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The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional
The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional regulatory domain but lacked the zinc finger DNA-binding domain, and thus the truncated Ex4a(+)WT1 isoform retained the ability to communicate with the transcriptional co-activators but misplaced a chance to bind to promoter of downstream targets. Prior scientific tests have demonstrated that the N-terminal domain