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A conservative assumption as the incremental cost of pregabalin compared to
A conservative assumption as the incremental cost of pregabalin compared to venlafaxine XR is higher for the mean doses than for the final doses. The assumption of no discontinuation could also be discussed, as it may be unrealistic, but it makes it possible to differentiate the consequences attributable to the initial treatments from the options that patients could change to. The sensitivity anal
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Cal study could be a weakness of this analysis, the strength
Cal study could be a weakness of this analysis, the strength derived from the direct comparison should also be acknowledged. Furthermore, the trial considered is the only one comparing flexible doses of pregabalin and venlafaxine XR, which is a more appropriate approach than assuming fixed doses. The placebo-adjusted effect size of pregabalin in this trial is similar to the effect estimated in oth
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Ld be beneficial for {better|much
Ld be practical for much better understanding of the system of WTLd be practical for improved understanding of the mechanism of WT1-mediated leukemogenesis and tumorigenesis. Within this review, Ex4a(+)WT1 isoform inhibited the transcriptional activation of Bcl-xL and Bcl-2 genes by major WT1 isoform [17AA(+)KTS(-)WT1]. It had been claimed that significant WT1 isoform exerts transcriptional
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H drugs [16]. Either in NICE evaluation or in the first application
H drugs [16]. Either in NICE evaluation or in the first application of the model used in this study [9] it is concluded that pregabalin is associated to more QALYs. However, given the divergences in clinical inputs, the magnitude of the gains is different. In a recent work [33], the authors also concluded for the cost-effectiveness of pregabalin vs. SSRIs/SNRIs in benzodiazepine-refractory outpati