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NPs can be made from many different polymer types including naturalNPs can be made from many different polymer types including natural or synthetic polymers such as poly-d,l-lactide-co-glycolide (PLGA), polylactic acid (PLA), poly--caprolactone (PCL), chitosan, gelatin, poly-alkyl-cyano-acrylates (PAC), gamma polyglutamic acid (-PGA), hyaluronan [or hyaluronic [34,35,39] acid (HA)] . However