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1
The hypotheses assumed. Only if the time horizon was set to
The hypotheses assumed. Only if the time horizon was set to 8 weeks, there would be an important increase on the incremental cost utility ratio. In fact, for a time horizon of 8 weeks the cost per QALY is 58,093. However, it should be clarified that the time horizon for economic evaluations of drugs is often extended beyond the duration of the clinical trial. This is so because clinical trials are
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Rse events or lack of efficacy and that, according to the
Rse events or lack of efficacy and that, according to the expert panel, they would switch to paroxetine, whose mean change from baseline was set at 50 , based on published data [24-27]. This was also assumed for those patients for whom the panel indicated a concomitant use of venlafaxine andSilva Miguel et al. Cost Effectiveness and Resource Allocation 2013, 11:8 http://www.resource-allocation.com
1
Rse events or lack of efficacy and that, according to the
Rse events or lack of efficacy and that, according to the expert panel, they would switch to paroxetine, whose mean change from baseline was set at 50 , based on published data [24-27]. This was also assumed for those patients for whom the panel indicated a concomitant use of venlafaxine andSilva Miguel et al. Cost Effectiveness and Resource Allocation 2013, 11:8 http://www.resource-allocation.com
1
Efficacy and adverse events (and consequent switch) was assumed. The cost-effectiveness
Efficacy and adverse events (and consequent switch) was assumed. The cost-effectiveness acceptability curve derived from the probabilistic sensitivity analysis on the weekly mean percentage changes from baseline in the HAM-A score is shown on Figure 2. It is possible to see that 90 of the cases are below an ICER of 28.2 thousand euros.pregabalin, in which the switch specified by the panel was to
1
Cal study could be a weakness of this analysis, the strength
Cal study could be a weakness of this analysis, the strength derived from the direct comparison should also be acknowledged. Furthermore, the trial considered is the only one comparing flexible doses of pregabalin and venlafaxine XR, which is a more appropriate approach than assuming fixed doses. The placebo-adjusted effect size of pregabalin in this trial is similar to the effect estimated in oth
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A conservative assumption as the incremental cost of pregabalin compared to
A conservative assumption as the incremental cost of pregabalin compared to venlafaxine XR is higher for the mean doses than for the final doses. The assumption of no discontinuation could also be discussed, as it may be unrealistic, but it makes it possible to differentiate the consequences attributable to the initial treatments from the options that patients could change to. The sensitivity anal
1
A conservative assumption as the incremental cost of pregabalin compared to
A conservative assumption as the incremental cost of pregabalin compared to venlafaxine XR is higher for the mean doses than for the final doses. The assumption of no discontinuation could also be discussed, as it may be unrealistic, but it makes it possible to differentiate the consequences attributable to the initial treatments from the options that patients could change to. The sensitivity anal
1
Efficacy and adverse events (and consequent switch) was assumed. The cost-effectiveness
Efficacy and adverse events (and consequent switch) was assumed. The cost-effectiveness acceptability curve derived from the probabilistic sensitivity analysis on the weekly mean percentage changes from baseline in the HAM-A score is shown on Figure 2. It is possible to see that 90 of the cases are below an ICER of 28.2 thousand euros.pregabalin, in which the switch specified by the panel was to